HAEMOLYTIC OF NEWBORN DISEASE-RELATED RED BLOOD CELL ALLOANTIBODIES

Red cell alloimmunisation in pregnancy may result haemolytic disease of the foetus and newborn (HDN). During pregnancy, there are possibilities foetal antigen being exposed to mother’s circulation, thereby leading production antibodies. The immunoglobulin G (IgG) antibodies from mother pass through maternal surface placenta, which is then sensitised obstructs formation red blood cells (RBCs). This review discusses presence variance alloantibodies during as well consequences HDN its management. revealed that ABO incompatibility most common cause pregnancy. Rh system (anti-D -E) found pregnant women, followed by other such Kell, Duffy, Kidd MNSs. Hyperbilirunemia (increased bilirubin levels) commonly seen neonatal jaundice due it usually manageable using phototherapy method. Nevertheless, clinical significance can complications anaemia, some extreme cases, kernicterus might require a exchange transfusion.